IJHS

Interprofessional Journal of Health Sciences

formerly Bulletin of Health, Science and Technology (BHST)

https://ijhs.rsu.ac.th

ISSN (Print) 2672-9628

ISSN (Online) 2672-9423

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Interprofessional Journal of Health Sciences. Vol.14 No.1 , January - June 2016.

CYTOTOXIC ACTIVITY OF RACEMOSAL AND DEMETHYLRACEMOSAL FROM BAUHINIA MALABARICA AGAINST HUMAN COLON CANCER COLO 205 CELLS
 

Suchada Jongrungruangchok, Nalinee Pradubyat, Thanapat Songsak, and Supakit Wongwiwatthananukit

Abstract

Bauhinia malabarica Roxb.(Caesalpiniaceae) has been used in Thai traditional medicine for analgesic, antiinflammatory, antineoplastic, antidiabetic, antiulcers, antileprosy, antibronchitis, antiamoebic, antidysenteric, and hypocholesterolemic. Racemosal and demethylracemosal were isolated from the root of B. malabarica and were identified by NMR spectroscopy and mass spectroscopy. MTT assay showed that racemosal and demethylracemosal significantly exhibited cytotoxic activity against human colon cancer colo 205cells exhibiting the IC50 values of  6.16 and 6.45 μM, respectively.

Keywords: Bauhinia malabarica, racemosal, demethylracemosal

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