IJHS
Interprofessional Journal of Health Sciences
formerly Bulletin of Health, Science and Technology (BHST)
https://ijhs.rsu.ac.th
ISSN (Print) 2672-9628
ISSN (Online) 2672-9423
Interprofessional Journal of Health Sciences. Vol.15 No.1 , January - June 2017.
ANGIOTENSIN I-CONVERTING ENZYME INHIBITOR ACTIVITY OF SOME MEDICINAL PLANTS LISTED IN TRADITIONAL THAI MEDICINE
Fameera Madaka, Pathamaporn Pathompak, Apirak Sakunpak, Chaowalit Monton1, and Tossaton Charoonratana
Abstract
The ethanolic extracts of selected medicinal plants were screened for angiotensin I-converting enzyme (ACEi) inhibitor activity. The plants comprised of four Apiaceae (Cuminum cyminum, Anethum graveolens, Foeniculum vulgare, Ligusticum sinense), one Apocynaceae (Dischidia major), two Combretaceae (Terminalia berllirica, Terminalia chebula), one Euphorbiaceae (Euphorbia antiquorum), two Calophyllaceae (Mammea siamensis, Mesue ferrea), two Fabaceae (Senna garrettiana, Albizia myriophylla), one Oleaceae (Jasminum sambac), one Malvaceae (Abroma augusta) and one Sapotaceae (Mimusops elengi). Reduction of hippuric acid, a product of substrate-ACE reaction, was determined using HPLC-UV technique. From the result, the ethanolic extracts of M. siamensis flower and S. garrettiana heartwood at the concentration 1 mg/ml showed high ACE inhibitor activity at 97.5 and 92.2 percent, respectively. This finding may supported that M. siamensis and S. garrettiana possessed ACE inhibitor compounds which either can be utilized as anti-hypertensive drugs, or as markers for quality control of traditional Thai medicine
Keywords: angiotensin I-converting enzyme, hippuric acid, Senna garrettiana