IJHS
Interprofessional Journal of Health Sciences
formerly Bulletin of Health, Science and Technology (BHST)
https://ijhs.rsu.ac.th
ISSN (Print) 2672-9628
ISSN (Online) 2672-9423
Interprofessional Journal of Health Sciences. Vol.16 No.1 , January - June 2018.
EFFECT OF CURCUMIN ON GLYCEMIC CONTROL AND METABOLIC PARAMETERS IN PREDIABETES AND DIABETES
Naeti Suksomboon, Nalinee Poolsup, and Putu Dian Marani Kurnianta
Abstract
The trend of adding natural medicines for diabetes treatment is uprising. Curcumin, commercially available as mixture of curcuminoids, is one of natural substance which has antidiabetic activities including insulin secretagogue and insulin sensitizer. Possible mechanisms include attenuation of tumor necrosis factor-alpha (TNF-α) and plasma free fatty acid (FFA) as well as activation of peroxisome proliferator-activated receptor gamma (PPAR-γ). This systematic review was aimed to evaluate the effect of curcumin on glycemic control and metabolic parameters in prediabetes and diabetes. Literature review up to November 2017 was undertaken in Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), The Cumulative Index to Nursing and Allied Health Literature (CINAHL), National Center for Complementary and Integrative Health (NCCIH), Scopus, ScienceDirect, Web of Science, ProQuest Dissertations and Theses (PQDT), etc. Twelve trials (N=459) met the eligibility criteria and were included. The results indicated that curcuminoids may offer benefits for prediabetes and type 2 diabetes mellitus (T2DM) with tolerable safety profile. Regardless of the varied settings of the included trials, curcuminoids tended to reduce fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) in these populations. Additionally, the improvement was likely observed on lipid profile, such as triglyceride and cholesterol. The available evidence also suggested that giving curcuminoids might be a good strategy to prevent the development of T2DM in prediabetes. Notwithstanding the beneficial effects of curcumin on glycemic control and lipid profile, the recent data may encourage higher quality trials with longer duration to establish the role of curcumin in clinical application, particularly in diabetes management.
Keywords: Curcumin, diabetes, prediabetes, glucose