Interprofessional Journal of Health Sciences. Vol.16 No.2 , July - December 2018.

STRUCTURAL MODIFICATION OF CYTOTOXIC SERRATENEDIOL FROM LYCOPODIACEAE PLANT

Sasiwadee Boonya-udtayan, Nopporn Thasana, Kwanrudee Mongkolchat, Kanyanut Boontan, Piyanus Chaisue, and Parichat Pansri

Abstract

Serratenediol (1), cytotoxic natural product, from L.phlegmaria (traditional herbal medicine) were isolated and purified by chromatographic method. Structural modification of isolated serratenediols (1) was studied by oxidation reaction, which included the oxidation of hydroxyl groups and epoxidation of carbon double bond, to provide the new carbonyl compound (2) and oxirane derivatives (3). The obtained product 2 and 3 were identified by spectroscopic method. The carbonyl product 2 was obtained in 67.8% by using chromium trioxide in the presence of pyridine at room temperature. Meanwhile, the epoxidation reaction was carried out by using meta-chloroperbenzoic acid to produce product 3 in 62.9%. This work achieved to find the reaction conditions to create new derivatives of serratenediol (2, 3).

Keywords: Serratenediol, Lycopodiaceae, structural modification

Download Full Paper.

DOI: 10.14456/ijhs.2018.2